Diazepam is categorized as which pregnancy category?

• A. A
• B. D
• C. B
• D. C

Answer: (B)

Diazepam carries fetal risk, so it is placed in a higher fetal-risk category. In the traditional FDA labeling, it is Category D, meaning there is positive evidence of human fetal harm, and the potential benefits to the mother might justify use only when no safer alternatives exist and the mother's health is at serious risk. Diazepam crosses the placenta and can cause fetal CNS depression and, if given near term, neonatal sedation or respiratory depression and withdrawal. Because of these risks, benzodiazepines are generally avoided in pregnancy unless absolutely necessary. Modern labeling uses a narrative format, but the takeaway remains that diazepam is associated with fetal risk and is not preferred in pregnancy.