In suspected ACS, what form of aspirin is recommended?

• A. Chewable
• B. Enteric-coated
• C. Caplet
• D. Liquid

Answer: (A)

Rapid antiplatelet action is essential in suspected ACS. Aspirin works by irreversibly inhibiting COX-1 in platelets, blocking thromboxane A2 and reducing further clot formation; this effect lasts for the life of the platelet, making early administration impactful.

Chewable aspirin is preferred because chewing disrupts the tablet and allows rapid absorption from the mouth and stomach, producing a faster onset of antiplatelet effect than swallowing a whole tablet. A typical acute-dose is about 162-325 mg chewed or crushed to maximize quick platelet inhibition.

Using a non-enteric-coated form supports prompt absorption; enteric-coated tablets can delay dissolution and delay the antiplatelet effect, which is undesirable in an acute event. While standard caplets or liquid forms can still work, they are not as reliably rapid as chewable aspirin in this setting.