Maximum single-dose Diazepam in adults

• A. 10 mg
• B. 30 mg
• C. 50 mg
• D. 100 mg

Answer: (B)

The key idea is safety in benzodiazepine dosing: there is a limit to how much diazepam you give in a single administration because of its strong CNS depressant effects and its long half-life, which can lead to accumulation. In adults, the maximum single-dose is 30 mg. This limit helps reduce the risk of severe sedation, respiratory depression, hypotension, and potential respiratory compromise, especially in people with other CNS depressants, liver impairment, or advanced age.

In everyday practice, typical initial or mild anxiolytic dosing is 2-10 mg, given as needed, and higher doses may be used for conditions like severe agitation or seizures, but should not exceed 30 mg in a single dose. If signs of excessive sedation or respiratory depression appear, reduce the dose and monitor closely. Remember that diazepam’s long duration means repeated or high dosing can lead to accumulation, so use the lowest effective dose and reassess frequently.