What is a common IV dose for metoclopramide used in the ED?

• A. 5 mg IV
• B. 10 mg IV
• C. 15 mg IV
• D. 20 mg IV

Answer: (B)

In the ED, the standard IV dose of metoclopramide for rapid antiemetic effect is 10 mg. This amount provides quick relief—often within minutes—and a duration of several hours without adding meaningful benefit from higher doses. Doses greater than 10 mg tend to increase the risk of extrapyramidal symptoms (such as dystonias or akathisia) and sedation, with little extra antiemetic advantage. A smaller dose, like 5 mg, may be used in patients who are at higher risk for these side effects or who are particularly frail, but it is less common as the routine adult ED dose. Administer it slowly, typically over a couple of minutes, to minimize potential side effects.