What is the onset of action of nitroglycerin after sublingual administration?

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Multiple Choice

What is the onset of action of nitroglycerin after sublingual administration?

Explanation:
Sublingual nitroglycerin works so quickly because it’s absorbed directly through the sublingual mucosa into the bloodstream, bypassing the liver’s first-pass metabolism. That rapid entry into circulation produces vasodilation that relieves angina within minutes. The typical onset is about 1-3 minutes, which is why this route is preferred for acute chest pain episodes. Times like 30-60 seconds are unusually fast for a tablet, while 10-15 minutes or 30-60 minutes would be too slow to treat an acute angina attack.

Sublingual nitroglycerin works so quickly because it’s absorbed directly through the sublingual mucosa into the bloodstream, bypassing the liver’s first-pass metabolism. That rapid entry into circulation produces vasodilation that relieves angina within minutes. The typical onset is about 1-3 minutes, which is why this route is preferred for acute chest pain episodes. Times like 30-60 seconds are unusually fast for a tablet, while 10-15 minutes or 30-60 minutes would be too slow to treat an acute angina attack.

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