What is the purpose of digoxin immune Fab in digoxin toxicity?

• A. To neutralize circulating digoxin and bind the molecule
• B. To increase digoxin production
• C. To enhance digoxin absorption
• D. To enhance digoxin receptor sensitivity

Answer: (A)

Digoxin immune Fab works by directly binding circulating digoxin with high affinity, forming non-toxic immune complexes that are cleared by the kidneys. By neutralizing the free digoxin, the inhibition of Na+/K+-ATPase is reversed, rapidly reducing toxicity and its effects on the heart and conduction. This approach targets the toxin itself rather than increasing production, absorption, or receptor sensitivity, which is why it is the appropriate antidote for digoxin toxicity.