What is the typical dose of Dextrose 50% for hypoglycemia in the ED?

• A. 25 g (50 mL of 50%) IV.
• B. 10 g (100 mL of 10%).
• C. 50 g (100 mL of 50%).
• D. 5 g (50 mL of 10%).

Answer: (A)

Rapid correction of hypoglycemia in the ED relies on a bolus of intravenous dextrose. Dextrose 50% delivers about 0.5 g per milliliter, so 50 mL provides 25 g of glucose. This 25 g dose is the standard initial amount that quickly raises blood glucose to restore cerebral function and resolve symptoms. If glucose remains low after rechecking, you can repeat the bolus or start a dextrose infusion with careful monitoring. Lower concentrations would require much larger volumes to reach the same 25 g dose and may delay correction, while a 50 g bolus would deliver too much glucose at once and isn’t the typical initial choice.