What is the typical induction dose of propofol for rapid sequence intubation (RSI)?

• A. 0.3 mg/kg IV
• B. 0.5 mg/kg IV
• C. 1–2 mg/kg IV
• D. 3–4 mg/kg IV

Answer: (C)

When preparing for rapid sequence intubation, you want a propofol dose that reliably produces loss of consciousness quickly without causing excessive blood pressure drop. The induction dose is typically 1–2 mg/kg given IV in adults. This range achieves rapid unconsciousness within seconds, facilitating a smooth intubation.

Doses much lower than this are unlikely to deepen anesthesia adequately for RSI and may require additional agents, while doses higher than this raise the risk of significant hypotension, apnea, and potential airway complications.

In practice, the exact amount can be adjusted based on the patient’s hemodynamic status and comorbidities, and adjuncts like analgesia (for example fentanyl) may be used to blunt the hemodynamic response to laryngoscopy.