What is the typical induction dose of etomidate for RSI?

• A. 0.1 mg/kg IV
• B. 0.5 mg/kg IV
• C. 1 mg/kg IV
• D. 0.3 mg/kg IV

Answer: (D)

Etomidate is chosen for RSI because it causes rapid hypnosis with minimal hemodynamic disturbance, allowing quick, controlled intubation. The typical induction dose is 0.3 mg/kg given intravenously. This amount reliably produces loss of consciousness within seconds and lasts only a few minutes, giving a good window for laryngoscopy without causing heavy, prolonged sedation. Using a smaller amount, like 0.1 mg/kg, may fail to achieve adequate depth of anesthesia for intubation, leading to movement or airway reflexes during laryngoscopy. Higher doses, such as 0.5 mg/kg or more, raise the risk of apnea and other adverse effects, and can lead to more pronounced suppression of adrenal function. While a single dose is generally well tolerated, the potential for adrenal suppression should be weighed in certain patients, such as those with septic shock.