Which is a listed side effect of epinephrine 1:1000?

• A. Nervousness
• B. Weight gain
• C. Hearing loss
• D. Hair loss

Answer: (A)

Epinephrine activates both alpha and beta adrenergic receptors, causing a surge of sympathetic activity. In the IM 1:1000 dose used for emergencies like anaphylaxis, this often manifests first as nervousness or jitteriness due to central nervous system stimulation and peripheral adrenergic effects. Nervousness is a well-recognized, common side effect of this preparation.

Weight gain, hearing loss, and hair loss are not typical acute adverse effects of epinephrine in this context. Weight gain is more associated with longer-term or different therapies, and hearing or hair changes are not standard adverse effects listed for epinephrine administration.