Which of the following is a known side effect of Albuterol?

• A. Cough
• B. Rash
• C. Tremors
• D. Hypotension

Answer: (C)

Albuterol’s known side effect is tremors because activating beta-2 receptors in skeletal muscle increases excitability in those muscles, producing a fine, visible tremor. This is dose-related and stems from the same beta-2–driven mechanism that relaxes bronchial smooth muscle; some drug enters systemic circulation with inhalation, tipping the balance toward jitteriness. Tremor is a classic, common adverse effect and often diminishes with time or with using techniques to limit systemic absorption, such as a spacer. Cough can occur from inhalation irritation or technique, but it’s not as characteristic. Rash is uncommon, and hypotension is not typical with inhaled beta-agonists.