Which precaution is associated with aspirin use?

• A. Pregnancy category D; caution in asthma; caution in renal impairment
• B. No precautions needed
• C. Use in pregnancy category A
• D. Avoid in asthma

Answer: (A)

Aspirin has several precautions because its effects extend beyond pain relief and fever reduction; its antiplatelet action and NSAID properties bring risks in specific situations. In pregnancy, aspirin is categorized as D because there is evidence of fetal harm, especially with continued use later in pregnancy, including potential disruption of normal fetal circulation and increased bleeding risk for the mother and fetus. In asthma, aspirin can trigger bronchospasm in individuals who are aspirin-sensitive, a phenomenon known as aspirin-exacerbated respiratory disease, so it should be avoided or used with great caution in asthmatic patients. In those with renal impairment, aspirin can worsen kidney function by inhibiting prostaglandin-mediated renal blood flow, increasing the risk of acute kidney injury, especially with other risk factors or dehydration. These precautions reflect the need to weigh benefits against potential serious harms in these populations, making the listed precautions the most appropriate concerns for aspirin use.